We evaluated the analytical sensitivity, specificity and diagnostic accuracy of each method for antibodies to Sm, RNP, Ro60, Ro52, Scl70, CENP-B and Jo1. Sera were collected in 15 centers belonging to the Study Group on Autoimmune Diseases of the Italian Society of Clinical Pathology and Laboratory Medicine. Sixty patients suffering from different SARD, 10 inflammatory arthritis patients (disease controls) and 10 healthy blood donors were included in this comparative study. In this study we compared eight different immunoassays, commonly used in current laboratory practice for detection of anti-ENA antibodies. However, data regarding the comparability of results obtained using different technologies across different platforms are scarce. In recent years, newly developed methods have enabled the simultaneous and quantitative detection of multiple anti-ENA reactivities. Autoantibodies against extractable nuclear antigens (ENA) play a pivotal role in the diagnosis and classification of systemic autoimmune rheumatic diseases (SARD).
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